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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

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Beyond serving as substrates, KBs and ketogenic diets (KD) may enhance mitochondrial function by promoting mitochondrial biogenesis via NAD⁺-dependent signalling pathways involving SIRT1/2/3, AMPK, PGC-1α, and FOXO1/3a, and by increasing mitochondrial respiration through PGC-1α–mediated effects on respiratory complexes (e.g., complex I/II)